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● 학위논문 - 석사: In silico and In vitro Analysis of Anti-Inflammatory Activity of Ginsenosides Rh2, Ck, Rh1 and F1 in LPS-Stimulated RAW264.7 Cells, 경희대학교 - 박사: Effects of Ginsenoside Rf on Immune-mediated Inflammatory Bowel Diseases and Atopic Dermatitis, 경희대학교 ● 연구실적 - SCIE 국제학술지: 42편 발표 - 특허: 등록 7건, 출원 12건 ● SCIE 국제 학술지 1. Ahn, S., Simu, S. Y., Yang, D. C., Jang, M., & Um, B. H. (2021). Effects of Ginsenoside Rf on dextran sodium sulfate-induced colitis in mice. Food and Agricultural Immunology, 32(1), 360-372. 2. Ahn, S., Singh, P., Kang, J. P., Veronika, S., Huo, Y., Singh, H., ... & Yang, D. C. (2018). In vitro anti-inflammatory activity of spherical silver nanoparticles and monodisperse hexagonal gold nanoparticles by fruit extract of Prunus serrulata: a green synthetic approach. Artificial cells, nanomedicine, and biotechnology, 46(8), 2022-2032. 3. Ahn, S., Singh, P., Jang, M., Kim, Y. J., Castro-Aceituno, V., Simu, S. Y., ... & Yang, D. C. (2018). Gold nanoflowers synthesized using Acanthopanacis cortex extract inhibit inflammatory mediators in LPS-induced RAW264. 7 macrophages via NF-κB and AP-1 pathways. Colloids and Surfaces B: Biointerfaces, 162, 398-404. 4. Ahn, S., Singh, P., Castro-Aceituno, V., Yesmin Simu, S., Kim, Y. J., Mathiyalagan, R., & Yang, D. C. (2017). Gold nanoparticles synthesized using Panax ginseng leaves suppress inflammatory-mediators production via blockade of NF-κB activation in macrophages. Artificial Cells, Nanomedicine, and Biotechnology, 45(2), 270-276. 5. Ahn, S., Cho, C. W., Lim, T. G., Hong, H. D., Rhee, Y. K., Yang, D. C., & Jang, M. (2017). Cynanchum wilfordii polysaccharides suppress dextran sulfate sodium-induced acute colitis in mice and the production of inflammatory mediators from macrophages. Mediators of inflammation, 2017. 6. Ahn, S., Siddiqi, M. H., Aceituno, V. C., Simu, S. Y., & Yang, D. C. (2016). Suppression of MAPKs/NF-κB activation induces intestinal anti-inflammatory action of ginsenoside Rf in HT-29 and RAW264. 7 cells. Immunological Investigations, 45(5), 439-449. 7. Ahn, S., Siddiqi, M. H., Aceituno, V. C., Simu, S. Y., Zhang, J., Jimenez Perez, Z. E., ... & Yang, D. C. (2016). Ginsenoside Rg5: Rk1 attenuates TNF-α/IFN-γ-induced production of thymus-and activation-regulated chemokine (TARC/CCL17) and LPS-induced NO production via downregulation of NF-κB/p38 MAPK/STAT1 signaling in human keratinocytes and macrophages. In Vitro Cellular & Developmental Biology-Animal, 52(3), 287-295. 8. Ahn, S., Siddiqi, M. H., Noh, H. Y., Kim, Y. J., Kim, Y. J., Jin, C. G., & Yang, D. C. (2015). Anti-inflammatory activity of ginsenosides in LPS-stimulated RAW 264.7 cells. Science bulletin, 60(8), 773-784. 9. Yi, M. H., Simu, S. Y., Ahn, S., Aceituno, V. C., Wang, C., Mathiyalagan, R., ... & Yang, D. C. (2020). Anti-obesity effect of gold nanoparticles from Dendropanax morbifera Léveille by suppression of triglyceride synthesis and downregulation of PPARγ and CEBPα signaling pathways in 3T3-L1 mature adipocytes and HepG2 cells. Current Nanoscience, 16(2), 196-203. 10. Mathiyalagan, R., Wang, C., Kim, Y. J., Castro-Aceituno, V., Ahn, S., Subramaniyam, S., ... & Jung, S. K. (2019). Preparation of polyethylene glycol-ginsenoside Rh1 and Rh2 conjugates and their efficacy against lung cancer and inflammation. Molecules, 24(23), 4367.. 11. Chokkalingam, M., Singh, P., Huo, Y., Soshnikova, V., Ahn, S., Kang, J., ... & Yang, D. C. (2019). Facile synthesis of Au and Ag nanoparticles using fruit extract of Lycium chinense and their anticancer activity. Journal of Drug Delivery Science and Technology, 49, 308-315. 12. Simu, S. Y., Ahn, S., Castro-Aceituno, V., Singh, P., Mathiyalagan, R., Jiménez-Pérez, Z. E., ... & Yang, D. C. (2019). Gold nanoparticles synthesized with fresh Panax ginseng leaf extract suppress adipogenesis by downregulating PPARγ/CEBPα signaling in 3T3-L1 mature adipocytes. Journal of Nanoscience and Nanotechnology, 19(2), 701-708. 13. Noh, H. Y., Lu, J., Siddiqi, M. H., Natatajan, S., Kang, S., Ahn, S., ... & Yang, D. C. (2018). Computational investigation of ginsenoside F1 from Panax ginseng meyer as p38 MAP kinase inhibitor: molecular docking and dynamics simulations, ADMET analysis, and drug likeness prediction. Iranian Journal of Pharmaceutical Research: IJPR, 17(4), 1318. 14. Yang, D. U., Siddiqi, M. H., Ahn, S., Kang, S., Noh, H. Y., & Yang, D. C. (2018). In vitro evaluation of the potential therapeutic role of Dendropanax morbifera extract in ameliorating osteoporosis and resultant bone impairment using MC3T3-E1 cells. In Vitro Cellular & Developmental Biology-Animal, 54(5), 346-354. 15. Jiménez-Pérez, Z. E., Kim, Y. J., Castro-Aceituno, V., Mathiyalagan, R., Markus, J., Ahn, S., ... & Yang, D. C. (2017). Novel application of cultured roots of mountain ginseng (Panax ginseng meyer) and ginsenoside re as safe antimelanogenic cosmeceutical components. African Journal of Traditional, Complementary and Alternative Medicines, 14(5), 209-218. 16. Simu, S. Y., Castro‐Aceituno, V., Lee, S., Ahn, S., Lee, H. K., Hoang, V. A., & Yang, D. C. (2018). Fermentation of soybean hull by Monascus pilosus and elucidation of its related molecular mechanism involved in the inhibition of lipid accumulation. An in sílico and in vitro approach. Journal of Food Biochemistry, 42(1), e12442. 17. Kang, J. P., Kim, Y. J., Singh, P., Huo, Y., Soshnikova, V., Markus, J., ... & Yang, D. C. (2018). Biosynthesis of gold and silver chloride nanoparticles mediated by Crataegus pinnatifida fruit extract: in vitro study of anti-inflammatory activities. Artificial Cells, Nanomedicine, and Biotechnology, 46(8), 1530-1540. 18. Hurh, J., Markus, J., Kim, Y. J., Ahn, S., Castro-Aceituno, V., Mathiyalagan, R., ... & Yang, D. C. (2017). Facile reduction and stabilization of ginsenoside-functionalized gold nanoparticles: optimization, characterization, and in vitro cytotoxicity studies. Journal of Nanoparticle Research, 19(9), 1-13. 19. Castro-Aceituno, V., Abbai, R., Moon, S. S., Ahn, S., Mathiyalagan, R., Kim, Y. J., ... & Yang, D. C. (2017). Pleuropterus multiflorus (Hasuo) mediated straightforward eco-friendly synthesis of silver, gold nanoparticles and evaluation of their anti-cancer activity on A549 lung cancer cell line. Biomedicine & Pharmacotherapy, 93, 995-1003. 20. Singh, P., Singh, H., Castro-Aceituno, V., Ahn, S., Kim, Y. J., Farh, M. E. A., & Yang, D. C. (2017). Engineering of mesoporous silica nanoparticles for release of ginsenoside CK and Rh2 to enhance their anticancer and anti-inflammatory efficacy: in vitro studies. Journal of Nanoparticle Research, 19(7), 1-14. 21. Oh, K. H., Soshnikova, V., Markus, J., Kim, Y. J., Lee, S. C., Singh, P., ... & Yang, D. C. (2018). Biosynthesized gold and silver nanoparticles by aqueous fruit extract of Chaenomeles sinensis and screening of their biomedical activities. Artificial cells, nanomedicine, and biotechnology, 46(3), 599-606. 22. Singh, P., Kim, Y. J., Singh, H., Ahn, S., Castro-Aceituno, V., & Yang, D. C. (2017). In situ preparation of water-soluble ginsenoside Rh2-entrapped bovine serum albumin nanoparticles: in vitro cytocompatibility studies. International journal of nanomedicine, 12, 4073. 23. Simu, S. Y., Siddiqi, M. H., Ahn, S., Castro-Aceituno, V., Kumar, N. S., Perez, Z. E. J., & Yang, D. C. (2017). Ginsenoside F1 attenuates lipid accumulation and triglycerides content in 3T3-L1 adipocytes with the modulation of reactive oxygen species (ROS) production through PPAR-γ/JAK2 signaling responses. Medicinal Chemistry Research, 26(5), 1042-1051. 24. Huo, Y., Singh, P., Kim, Y. J., Soshnikova, V., Kang, J., Markus, J., ... & Yang, D. C. (2018). Biological synthesis of gold and silver chloride nanoparticles by Glycyrrhiza uralensis and in vitro applications. Artificial cells, nanomedicine, and biotechnology, 46(2), 303-312. 25. Soshnikova, V., Kim, Y. J., Singh, P., Huo, Y., Markus, J., Ahn, S., ... & Yang, D. C. (2018). Cardamom fruits as a green resource for facile synthesis of gold and silver nanoparticles and their biological applications. Artificial cells, nanomedicine, and biotechnology, 46(1), 108-117. 26. Singh, P., Singh, H., Castro-Aceituno, V., Ahn, S., Kim, Y. J., & Yang, D. C. (2017). Bovine serum albumin as a nanocarrier for the efficient delivery of ginsenoside compound K: preparation, physicochemical characterizations and in vitro biological studies. RSC advances, 7(25), 15397-15407. 27. Markus, J., Wang, D., Kim, Y. J., Ahn, S., Mathiyalagan, R., Wang, C., & Yang, D. C. (2017). Biosynthesis, characterization, and bioactivities evaluation of silver and gold nanoparticles mediated by the roots of Chinese herbal Angelica pubescens Maxim. Nanoscale Research Letters, 12(1), 1-12. 28. Wang, D., Markus, J., Kim, Y. J., Wang, C., Pérez, Z. E. J., Ahn, S., ... & Yang, D. C. (2016). Coalescence of functional gold and monodisperse silver nanoparticles mediated by black Panax ginseng Meyer root extract. International journal of nanomedicine, 11, 6621. 29. Wang, D., Markus, J., Wang, C., Kim, Y. J., Mathiyalagan, R., Aceituno, V. C., ... & Yang, D. C. (2017). Green synthesis of gold and silver nanoparticles using aqueous extract of Cibotium barometz root. Artificial cells, nanomedicine, and biotechnology, 45(8), 1548-1555. 30. Singh, P., Singh, H., Ahn, S., Castro-Aceituno, V., Jiménez, Z., Simu, S. Y., ... & Yang, D. C. (2017). Pharmacological importance, characterization and applications of gold and silver nanoparticles synthesized by Panax ginseng fresh leaves. Artificial Cells, Nanomedicine, and Biotechnology, 45(7), 1415-1424. 31. Jang, M., Lim, T. G., Ahn, S., Hong, H. D., Rhee, Y. K., Kim, K. T., ... & Cho, C. W. (2016). Immune-enhancing effects of a high molecular weight fraction of Cynanchum wilfordii Hemsley in macrophages and immunosuppressed mice. Nutrients, 8(10), 600. 32. Castro-Aceituno, V., Siddiqi, M. H., Ahn, S., Sathishkumar, N., Noh, H. Y., Simu, S. Y., ... & Yang, D. C. (2016). The inhibitory mechanism of compound K on A549 lung cancer cells through EGF pathway: an in silico and in vitro approach. Current Science, 1071-1077. 33. Castro-Aceituno, V., Ahn, S., Simu, S. Y., Singh, P., Mathiyalagan, R., Lee, H. A., & Yang, D. C. (2016). Anticancer activity of silver nanoparticles from Panax ginseng fresh leaves in human cancer cells. Biomedicine & Pharmacotherapy, 84, 158-165. 34. Markus, J., Mathiyalagan, R., Kim, Y. J., Abbai, R., Singh, P., Ahn, S., ... & Yang, D. C. (2016). Intracellular synthesis of gold nanoparticles with antioxidant activity by probiotic Lactobacillus kimchicus DCY51T isolated from Korean kimchi. Enzyme and microbial technology, 95, 85-93. 35. Wang, C., Mathiyalagan, R., Kim, Y. J., Castro-Aceituno, V., Singh, P., Ahn, S., ... & Yang, D. C. (2016). Rapid green synthesis of silver and gold nanoparticles using Dendropanax morbifera leaf extract and their anticancer activities. International journal of nanomedicine, 11, 3691. 36. Abbai, R., Ramya Mathiyalagan, J. M., Kim, Y. J., Wang, C., Singh, P., Ahn, S., ... & Yang, D. C. (2016). Green synthesis of multifunctional silver and gold nanoparticles from the oriental herbal adaptogen: Siberian ginseng. International journal of nanomedicine, 11, 3131. 37. Kang, S., Siddiqi, M. H., Yoon, S. J., Ahn, S., Noh, H. Y., Kumar, N. S., ... & Yang, D. C. (2016). Therapeutic potential of compound K as an IKK inhibitor with implications for osteoarthritis prevention: an in silico and in vitro study. In Vitro Cellular & Developmental Biology-Animal, 52(9), 895-905. 38. Castro Aceituno, V., Ahn, S., Simu, S. Y., Wang, C., Mathiyalagan, R., & Yang, D. C. (2016). Silver nanoparticles from Dendropanax morbifera Léveille inhibit cell migration, induce apoptosis, and increase generation of reactive oxygen species in A549 lung cancer cells. In Vitro Cellular & Developmental Biology-Animal, 52(10), 1012-1019. 39. Siddiqi, M. H., Siddiqi, M. Z., Kang, S., Noh, H. Y., Ahn, S., Simu, S. Y., ... & Yang, D. C. (2015). Inhibition of osteoclast differentiation by ginsenoside Rg3 in RAW264. 7 cells via RANKL, JNK and p38 MAPK pathways through a modulation of cathepsin K: an in silico and in vitro study. Phytotherapy Research, 29(9), 1286-1294. 40. Siddiqi, M. H., Siddiqi, M. Z., Ahn, S., Kang, S., Kim, Y. J., Veerappan, K., ... & Yang, D. C. (2014). Stimulative effect of ginsenosides Rg5: Rk1 on murine osteoblastic MC3T3‐E1 cells. Phytotherapy Research, 28(10), 1447-1455. 41. Siddiqi, M. H., Siddiqi, M. Z., Ahn, S., Kim, Y. J., & Yang, D. C. (2014). Ginsenoside Rh1 induces mouse osteoblast growth and differentiation through the bone morphogenetic protein 2/runt-related gene 2 signalling pathway. Journal of Pharmacy and Pharmacology, 66(12), 1763-1773. 42. Siddiqi, M. H., Siddiqi, M. Z., Ahn, S., Kang, S., Kim, Y. J., Sathishkumar, N., ... & Yang, D. C. (2013). Ginseng saponins and the treatment of osteoporosis: mini literature review. Journal of Ginseng Research, 37(3), 261. |
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● 등록 특허 1. 생체이용성이 개선된 눈개승마 가공물 및 이의 제조방법, 2020, 등록번호: 1023808120000 2. 유산균을 포함하는 면역 증강용 조성물, 2018, 등록번호: 1020170058832 3. 히알루론산과 진세노사이드의 결합체 및 이의 용도, 2018, 등록번호: 1018719640000 4. 진세노사이드에 대해 당전이 활성을 가지는 단백질 및 이의 용도, 2018,등록번호: 1018568280000 5. 황칠 추출물을 포함하는 금속 나노입자의 제조용 조성물 및 이의 이용, 2017, 등록번호: 1017963700000 6. 두릅나무과 식물의 발효물을 포함하는 항염증 또는 항암용 조성물, 2017, 등록번호: 1017688060000 7. 메조다공성 실리카 나노입자와 진세노사이드의 결합체 및 이의 용도, 2017, 등록번호: 1017480790000 |
● 디딤돌 기초생물학 (정문각) | |
● 핵심 일반화학 (의학교육) | |
● 학위 논문 - 석사: 6-Hydroxydopamine-induced Nitrosative Cell Death and It’s Prevention by Korean Red Ginseng - 박사 : Development of Natural Resources for the Prevention and Treatment of Alzheimer's Disease via Activating Nrf2-HO-1 Signaling Pathway ● SCIE 논문 1. Lee C, Jang JH, Park GH. α-Pinene Attenuates Methamphetamine-Induced Conditioned Place Preference in C57BL/6 Mice. Biomol Ther (Seoul). 2023 Jul 1;31(4):411-416. PMID: 36733209 2. Lee C, Jang JH, Park GH. Protective Role of Corticosterone against Hydrogen Peroxide-Induced Neuronal Cell Death in SH-SY5Y Cells. Biomol Ther (Seoul). 2022 Nov 1;30(6):570-575. PMID: 36261216. 3. Lee G, Kim Y, Jang JH, Lee C, Yoon J, Ahn N, Kim K. Effects of an Exercise Program Combining Aerobic and Resistance Training on Protein Expressions of Neurotrophic Factors in Obese Rats Injected with Beta-Amyloid. Int J Environ Res Public Health. 2022 Jun 28;19(13):7921. PMID: 35805580. 4. Kim GM, Lee C, Jang TC. Zoletil promotes apoptosis in BV-2 microglial cells via induction of oxidative stress and neural inflammation. Toxicol Res (Camb). 2021 Dec 29;11(1):134-146. PMID: 35237418. 5. Kim CY, Seo Y, Lee C, Park GH, Jang JH. Neuroprotective Effect and Molecular Mechanism of [6]-Gingerol against Scopolamine-Induced Amnesia in C57BL/6 Mice. Evid Based Complement Alternat Med. 2018;2018:8941564. PMID: 29770155. 6. Sah SK, Lee C, Jang JH, Park GH. Effect of high-fat diet on cognitive impairment in triple-transgenic mice model of Alzheimer's disease. Biochem Biophys Res Commun. 2017, 4;493(1):731-736. PMID: 28865961. 7. Lee GY, Lee C, Park GH, Jang JH. Amelioration of Scopolamine-Induced Learning and Memory Impairment by α-Pinene in C57BL/6 Mice. Evid Based Complement Alternat Med. 2017;2017:4926815. PMID: 29234406. 8. Lee C, Park GH, Ahn EM, Park CI, Jang JH. Sargassum fulvellum Protects HaCaT Cells and BALB/c Mice from UVB-Induced Proinflammatory Responses. Evid Based Complement Alternat Med. 2013;2013:747846. PMID: 23935680. 9. Lee C, Park GH, Lee SR, Jang JH. Attenuation of β-amyloid-induced oxidative cell death by sulforaphane via activation of NF-E2-related factor 2. Oxid Med Cell Longev. 2013;2013:313510. PMID: 23864927. 10. LeeC, Park GH, Ahn EM, Kim BA, Park CI, Jang JH. Protective effect of Codium fragile against UVB-induced pro-inflammatory and oxidative damages in HaCaT cells and BALB/c mice. Fitoterapia. 2013, 86:54-63. PMID: 23396144. 11. Um HC, Jang JH, Kim DH, LeeC, Surh YJ. Nitric oxide activates Nrf2 through S-nitrosylation of Keap1 in PC12 cells. Nitric Oxide. 2011, 25(2):161-168. PMID: 21703357. 12. LeeC, Park GH, Jang JH. Cellular antioxidant adaptive survival response to 6-hydroxydopamine-induced nitrosative cell death in C6 glioma cells. Toxicology. 2011, 283(2-3):118-128. PMID: 21397656. 13. Lee C, Park GH, Kim CY, Jang JH. [6]-Gingerol attenuates β-amyloid-induced oxidative cell death via fortifying cellular antioxidant defense system. Food Chem. Toxicol. 2011, 49(6):1261-1269. PMID: 21396424. 14. Han HS, Jang JH, Jang JH, Choi JS, Kim YJ, LeeC, Lim SH, Lee HK, Lee J. Water extract of Triticum aestivum L. and its components demonstrate protective effect in a model of vascular dementia. J. Med. Food. 2010, 13(3):572-578. PMID: 20521983. 15. Kim CY, LeeC, Park GH, Jang JH. Neuroprotective effect of epigallocatechin-3-gallate against beta-amyloid-induced oxidative and nitrosative cell death via augmentation of antioxidant defense capacity. Arch. Pharm. Res. 2009, 32(6):869-881. PMID: 19557365. 16. Kim JW, Li MH, Jang JH, Na HK, Song NY, LeeC, Johnson JA, Surh YJ. 15-Deoxy-Delta(12,14)-prostaglandin J(2) rescues PC12 cells from H2O2-induced apoptosis through Nrf2-mediated upregulation of heme oxygenase-1: potential roles of Akt and ERK1/2. Biochem Pharmacol. 2008 Dec 1;76(11):1577-89. PMID: 18775681. ● 학진 등재 논문 1. 이길용, 이찬, 백정인, 배근영, 박찬익, 장정희. 사이프러스 에센셜 오일의 흡입이 전임상 실험동물의 손상된 학습능력과 기억력에 미치는 영양. 대한본초학회지, 35(5), 33~39 2. 이찬, 장정희, 박규환. 6-Hydroxydopamine으로 유도된 질소적 세포 사멸에 대한 고려홍삼 추출물의 보호효과. 약학회지, 60(2), 92~99 3. 이찬, 박규환, 이종원, 장정희. 베타아밀로이드로 유도된 신경세포 사멸과 기억력 손상에 대한 밀기울추출물의 보호효과. 대한본초학회지, 30(1), 67~75 4. 이찬, 장정희, 김보애, 박찬익. UVB로 손상이 유도된 피부세포에 해양소재 추출물의 항노화 효능. 대한화장품학회지, 38(3), 255~262 5. 이찬, 장정희, 안은미, 박찬익. B16 멜라닌 세포에서 해양소재 추출물의 멜라닌 생성 저해 효과. 대한본초학회지, 27(4), 73~80 6. 제갈경환, 박성준, 김창열, 이 찬, 박종현, 장정희. 스코폴라민으로 유도된 기억력 손상에 대한 복신의 보호 효과 및 작용기전 연구. 동의생리병리학회지, 24(2), 228~235 7. 장정희, 이찬, 김상찬, 정지욱, 박찬익. 자외선으로 유도된 섬유아세포 손상에 대한 해양소재 추출물의 항산화 보호효과. 대한화장품학회지, 36(1), 79~87 |
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● 특허 1. 알파피넨을 유효성분으로 함유하는 메스암페타민 중독 예방 또는 치료용 조성물. 2021. 등록번호: 1022741740000 2. 석결명 추출물을 포함하는 자외선으로 인한 피부 손상 예방 및 치료용 의약품 조성물. 2012. 등록번호: 1012024680000 3. 해룡 추출물을 포함하는 자외선으로 인한 피부 손상 예방 및 치료용 의약품 조성물. 2012. 등록번호: 1011948910000 4. 모려 추출물을 포함하는 자외선으로 인한 피부 손상 예방 및 치료용 의약품 조성물. 2012. 등록번호: 1011949070000 5. 알파-튜존을 유효 성분으로 함유하는 기억력 증진 및 인지 기능 장애 치료 및 예방을 위한 조성물. 2012. 등록번호: 1011486230000 6. 알파-피넨을 유효 성분으로 함유하는 기억력 증진 및 인지 기능 장애 치료 및 예방을 위한 조성물. 2012. 등록번호: 1011413550000 7. 생강 또는 건강 추출물을 유효성분으로 함유하는 건망증 및 기억력 장애 관련 질환의 예방 및 치료용 조성물. 2012. 등록번호: 1011414390000 8. 복신 건조분말 또는 그 추출물을 유효성분으로 함유하는 건망증 및 기억력 장애 관련 질환의 예방 및 치료용 조성물. 2011. 등록번호: 1010726620000 |
● 학위논문 - 알코올에 의해 유도된 간 CYP3A 발현에서 콜로스테롤 대사로 생성된 내인성 리간드인 Pregnane X receptor의 역할 |
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