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최종학력 및 경력
● 최종학력: 경희대학교 대학원 (이학박사)

● 경력:
－ 한국과학기술연구원(KIST)
－ 신일제약 생명과학연구소

● 주요 연구 분야
－ In silico 분자설계 및 비임상효능평가(In vitro/In vivo)
－ 추출/분리정제, 분석법 개발
－ 의약품 규제 과학
－ 통계적 품질관리 (SQC, Statistic Quality Control)
－ 의약품 품질고도화시스템(QbD, Quality by Design)
－ 기능성 나노복합체 개발
－ 천연물 유효성분 극대화 및 표준화 기술개발

● 평가위원:
－ Advanced Chemicobiology Research 편집위원
－ 농림축산식품 국가연구개발과제 평가위원
연구실적

	● 학위논문 － 석사: In silico and In vitro Analysis of Anti-Inflammatory Activity of Ginsenosides Rh2, Ck, Rh1 and F1 in LPS-Stimulated RAW264.7 Cells, 경희대학교 － 박사: Effects of Ginsenoside Rf on Immune-mediated Inflammatory Bowel Diseases and Atopic Dermatitis, 경희대학교 ● 연구실적 － SCIE 국제학술지: 42편 발표 － 특허: 등록 7건, 출원 12건 ● SCIE 국제 학술지 1. Ahn, S., Simu, S. Y., Yang, D. C., Jang, M., & Um, B. H. (2021). Effects of Ginsenoside Rf on dextran sodium sulfate-induced colitis in mice. Food and Agricultural Immunology, 32(1), 360-372. 2. Ahn, S., Singh, P., Kang, J. P., Veronika, S., Huo, Y., Singh, H., ... & Yang, D. C. (2018). In vitro anti-inflammatory activity of spherical silver nanoparticles and monodisperse hexagonal gold nanoparticles by fruit extract of Prunus serrulata: a green synthetic approach. Artificial cells, nanomedicine, and biotechnology, 46(8), 2022-2032. 3. Ahn, S., Singh, P., Jang, M., Kim, Y. J., Castro-Aceituno, V., Simu, S. Y., ... & Yang, D. C. (2018). Gold nanoflowers synthesized using Acanthopanacis cortex extract inhibit inflammatory mediators in LPS-induced RAW264. 7 macrophages via NF-κB and AP-1 pathways. Colloids and Surfaces B: Biointerfaces, 162, 398-404. 4. Ahn, S., Singh, P., Castro-Aceituno, V., Yesmin Simu, S., Kim, Y. J., Mathiyalagan, R., & Yang, D. C. (2017). Gold nanoparticles synthesized using Panax ginseng leaves suppress inflammatory-mediators production via blockade of NF-κB activation in macrophages. Artificial Cells, Nanomedicine, and Biotechnology, 45(2), 270-276. 5. Ahn, S., Cho, C. W., Lim, T. G., Hong, H. D., Rhee, Y. K., Yang, D. C., & Jang, M. (2017). Cynanchum wilfordii polysaccharides suppress dextran sulfate sodium-induced acute colitis in mice and the production of inflammatory mediators from macrophages. Mediators of inflammation, 2017. 6. Ahn, S., Siddiqi, M. H., Aceituno, V. C., Simu, S. Y., & Yang, D. C. (2016). Suppression of MAPKs/NF-κB activation induces intestinal anti-inflammatory action of ginsenoside Rf in HT-29 and RAW264. 7 cells. Immunological Investigations, 45(5), 439-449. 7. Ahn, S., Siddiqi, M. H., Aceituno, V. C., Simu, S. Y., Zhang, J., Jimenez Perez, Z. E., ... & Yang, D. C. (2016). Ginsenoside Rg5: Rk1 attenuates TNF-α/IFN-γ-induced production of thymus-and activation-regulated chemokine (TARC/CCL17) and LPS-induced NO production via downregulation of NF-κB/p38 MAPK/STAT1 signaling in human keratinocytes and macrophages. In Vitro Cellular & Developmental Biology-Animal, 52(3), 287-295. 8. Ahn, S., Siddiqi, M. H., Noh, H. Y., Kim, Y. J., Kim, Y. J., Jin, C. G., & Yang, D. C. (2015). Anti-inflammatory activity of ginsenosides in LPS-stimulated RAW 264.7 cells. Science bulletin, 60(8), 773-784. 9. Yi, M. H., Simu, S. Y., Ahn, S., Aceituno, V. C., Wang, C., Mathiyalagan, R., ... & Yang, D. C. (2020). Anti-obesity effect of gold nanoparticles from Dendropanax morbifera Léveille by suppression of triglyceride synthesis and downregulation of PPARγ and CEBPα signaling pathways in 3T3-L1 mature adipocytes and HepG2 cells. Current Nanoscience, 16(2), 196-203. 10. Mathiyalagan, R., Wang, C., Kim, Y. J., Castro-Aceituno, V., Ahn, S., Subramaniyam, S., ... & Jung, S. K. (2019). Preparation of polyethylene glycol-ginsenoside Rh1 and Rh2 conjugates and their efficacy against lung cancer and inflammation. Molecules, 24(23), 4367.. 11. Chokkalingam, M., Singh, P., Huo, Y., Soshnikova, V., Ahn, S., Kang, J., ... & Yang, D. C. (2019). Facile synthesis of Au and Ag nanoparticles using fruit extract of Lycium chinense and their anticancer activity. Journal of Drug Delivery Science and Technology, 49, 308-315. 12. Simu, S. Y., Ahn, S., Castro-Aceituno, V., Singh, P., Mathiyalagan, R., Jiménez-Pérez, Z. E., ... & Yang, D. C. (2019). Gold nanoparticles synthesized with fresh Panax ginseng leaf extract suppress adipogenesis by downregulating PPARγ/CEBPα signaling in 3T3-L1 mature adipocytes. Journal of Nanoscience and Nanotechnology, 19(2), 701-708. 13. Noh, H. Y., Lu, J., Siddiqi, M. H., Natatajan, S., Kang, S., Ahn, S., ... & Yang, D. C. (2018). Computational investigation of ginsenoside F1 from Panax ginseng meyer as p38 MAP kinase inhibitor: molecular docking and dynamics simulations, ADMET analysis, and drug likeness prediction. Iranian Journal of Pharmaceutical Research: IJPR, 17(4), 1318. 14. Yang, D. U., Siddiqi, M. H., Ahn, S., Kang, S., Noh, H. Y., & Yang, D. C. (2018). In vitro evaluation of the potential therapeutic role of Dendropanax morbifera extract in ameliorating osteoporosis and resultant bone impairment using MC3T3-E1 cells. In Vitro Cellular & Developmental Biology-Animal, 54(5), 346-354. 15. Jiménez-Pérez, Z. E., Kim, Y. J., Castro-Aceituno, V., Mathiyalagan, R., Markus, J., Ahn, S., ... & Yang, D. C. (2017). Novel application of cultured roots of mountain ginseng (Panax ginseng meyer) and ginsenoside re as safe antimelanogenic cosmeceutical components. African Journal of Traditional, Complementary and Alternative Medicines, 14(5), 209-218. 16. Simu, S. Y., Castro‐Aceituno, V., Lee, S., Ahn, S., Lee, H. K., Hoang, V. A., & Yang, D. C. (2018). Fermentation of soybean hull by Monascus pilosus and elucidation of its related molecular mechanism involved in the inhibition of lipid accumulation. An in sílico and in vitro approach. Journal of Food Biochemistry, 42(1), e12442. 17. Kang, J. P., Kim, Y. J., Singh, P., Huo, Y., Soshnikova, V., Markus, J., ... & Yang, D. C. (2018). Biosynthesis of gold and silver chloride nanoparticles mediated by Crataegus pinnatifida fruit extract: in vitro study of anti-inflammatory activities. Artificial Cells, Nanomedicine, and Biotechnology, 46(8), 1530-1540. 18. Hurh, J., Markus, J., Kim, Y. J., Ahn, S., Castro-Aceituno, V., Mathiyalagan, R., ... & Yang, D. C. (2017). Facile reduction and stabilization of ginsenoside-functionalized gold nanoparticles: optimization, characterization, and in vitro cytotoxicity studies. Journal of Nanoparticle Research, 19(9), 1-13. 19. Castro-Aceituno, V., Abbai, R., Moon, S. S., Ahn, S., Mathiyalagan, R., Kim, Y. J., ... & Yang, D. C. (2017). Pleuropterus multiflorus (Hasuo) mediated straightforward eco-friendly synthesis of silver, gold nanoparticles and evaluation of their anti-cancer activity on A549 lung cancer cell line. Biomedicine & Pharmacotherapy, 93, 995-1003. 20. Singh, P., Singh, H., Castro-Aceituno, V., Ahn, S., Kim, Y. J., Farh, M. E. A., & Yang, D. C. (2017). Engineering of mesoporous silica nanoparticles for release of ginsenoside CK and Rh2 to enhance their anticancer and anti-inflammatory efficacy: in vitro studies. Journal of Nanoparticle Research, 19(7), 1-14. 21. Oh, K. H., Soshnikova, V., Markus, J., Kim, Y. J., Lee, S. C., Singh, P., ... & Yang, D. C. (2018). Biosynthesized gold and silver nanoparticles by aqueous fruit extract of Chaenomeles sinensis and screening of their biomedical activities. Artificial cells, nanomedicine, and biotechnology, 46(3), 599-606. 22. Singh, P., Kim, Y. J., Singh, H., Ahn, S., Castro-Aceituno, V., & Yang, D. C. (2017). In situ preparation of water-soluble ginsenoside Rh2-entrapped bovine serum albumin nanoparticles: in vitro cytocompatibility studies. International journal of nanomedicine, 12, 4073. 23. Simu, S. Y., Siddiqi, M. H., Ahn, S., Castro-Aceituno, V., Kumar, N. S., Perez, Z. E. J., & Yang, D. C. (2017). Ginsenoside F1 attenuates lipid accumulation and triglycerides content in 3T3-L1 adipocytes with the modulation of reactive oxygen species (ROS) production through PPAR-γ/JAK2 signaling responses. Medicinal Chemistry Research, 26(5), 1042-1051. 24. Huo, Y., Singh, P., Kim, Y. J., Soshnikova, V., Kang, J., Markus, J., ... & Yang, D. C. (2018). Biological synthesis of gold and silver chloride nanoparticles by Glycyrrhiza uralensis and in vitro applications. Artificial cells, nanomedicine, and biotechnology, 46(2), 303-312. 25. Soshnikova, V., Kim, Y. J., Singh, P., Huo, Y., Markus, J., Ahn, S., ... & Yang, D. C. (2018). Cardamom fruits as a green resource for facile synthesis of gold and silver nanoparticles and their biological applications. Artificial cells, nanomedicine, and biotechnology, 46(1), 108-117. 26. Singh, P., Singh, H., Castro-Aceituno, V., Ahn, S., Kim, Y. J., & Yang, D. C. (2017). Bovine serum albumin as a nanocarrier for the efficient delivery of ginsenoside compound K: preparation, physicochemical characterizations and in vitro biological studies. RSC advances, 7(25), 15397-15407. 27. Markus, J., Wang, D., Kim, Y. J., Ahn, S., Mathiyalagan, R., Wang, C., & Yang, D. C. (2017). Biosynthesis, characterization, and bioactivities evaluation of silver and gold nanoparticles mediated by the roots of Chinese herbal Angelica pubescens Maxim. Nanoscale Research Letters, 12(1), 1-12. 28. Wang, D., Markus, J., Kim, Y. J., Wang, C., Pérez, Z. E. J., Ahn, S., ... & Yang, D. C. (2016). Coalescence of functional gold and monodisperse silver nanoparticles mediated by black Panax ginseng Meyer root extract. International journal of nanomedicine, 11, 6621. 29. Wang, D., Markus, J., Wang, C., Kim, Y. J., Mathiyalagan, R., Aceituno, V. C., ... & Yang, D. C. (2017). Green synthesis of gold and silver nanoparticles using aqueous extract of Cibotium barometz root. Artificial cells, nanomedicine, and biotechnology, 45(8), 1548-1555. 30. Singh, P., Singh, H., Ahn, S., Castro-Aceituno, V., Jiménez, Z., Simu, S. Y., ... & Yang, D. C. (2017). Pharmacological importance, characterization and applications of gold and silver nanoparticles synthesized by Panax ginseng fresh leaves. Artificial Cells, Nanomedicine, and Biotechnology, 45(7), 1415-1424. 31. Jang, M., Lim, T. G., Ahn, S., Hong, H. D., Rhee, Y. K., Kim, K. T., ... & Cho, C. W. (2016). Immune-enhancing effects of a high molecular weight fraction of Cynanchum wilfordii Hemsley in macrophages and immunosuppressed mice. Nutrients, 8(10), 600. 32. Castro-Aceituno, V., Siddiqi, M. H., Ahn, S., Sathishkumar, N., Noh, H. Y., Simu, S. Y., ... & Yang, D. C. (2016). The inhibitory mechanism of compound K on A549 lung cancer cells through EGF pathway: an in silico and in vitro approach. Current Science, 1071-1077. 33. Castro-Aceituno, V., Ahn, S., Simu, S. Y., Singh, P., Mathiyalagan, R., Lee, H. A., & Yang, D. C. (2016). Anticancer activity of silver nanoparticles from Panax ginseng fresh leaves in human cancer cells. Biomedicine & Pharmacotherapy, 84, 158-165. 34. Markus, J., Mathiyalagan, R., Kim, Y. J., Abbai, R., Singh, P., Ahn, S., ... & Yang, D. C. (2016). Intracellular synthesis of gold nanoparticles with antioxidant activity by probiotic Lactobacillus kimchicus DCY51T isolated from Korean kimchi. Enzyme and microbial technology, 95, 85-93. 35. Wang, C., Mathiyalagan, R., Kim, Y. J., Castro-Aceituno, V., Singh, P., Ahn, S., ... & Yang, D. C. (2016). Rapid green synthesis of silver and gold nanoparticles using Dendropanax morbifera leaf extract and their anticancer activities. International journal of nanomedicine, 11, 3691. 36. Abbai, R., Ramya Mathiyalagan, J. M., Kim, Y. J., Wang, C., Singh, P., Ahn, S., ... & Yang, D. C. (2016). Green synthesis of multifunctional silver and gold nanoparticles from the oriental herbal adaptogen: Siberian ginseng. International journal of nanomedicine, 11, 3131. 37. Kang, S., Siddiqi, M. H., Yoon, S. J., Ahn, S., Noh, H. Y., Kumar, N. S., ... & Yang, D. C. (2016). Therapeutic potential of compound K as an IKK inhibitor with implications for osteoarthritis prevention: an in silico and in vitro study. In Vitro Cellular & Developmental Biology-Animal, 52(9), 895-905. 38. Castro Aceituno, V., Ahn, S., Simu, S. Y., Wang, C., Mathiyalagan, R., & Yang, D. C. (2016). Silver nanoparticles from Dendropanax morbifera Léveille inhibit cell migration, induce apoptosis, and increase generation of reactive oxygen species in A549 lung cancer cells. In Vitro Cellular & Developmental Biology-Animal, 52(10), 1012-1019. 39. Siddiqi, M. H., Siddiqi, M. Z., Kang, S., Noh, H. Y., Ahn, S., Simu, S. Y., ... & Yang, D. C. (2015). Inhibition of osteoclast differentiation by ginsenoside Rg3 in RAW264. 7 cells via RANKL, JNK and p38 MAPK pathways through a modulation of cathepsin K: an in silico and in vitro study. Phytotherapy Research, 29(9), 1286-1294. 40. Siddiqi, M. H., Siddiqi, M. Z., Ahn, S., Kang, S., Kim, Y. J., Veerappan, K., ... & Yang, D. C. (2014). Stimulative effect of ginsenosides Rg5: Rk1 on murine osteoblastic MC3T3‐E1 cells. Phytotherapy Research, 28(10), 1447-1455. 41. Siddiqi, M. H., Siddiqi, M. Z., Ahn, S., Kim, Y. J., & Yang, D. C. (2014). Ginsenoside Rh1 induces mouse osteoblast growth and differentiation through the bone morphogenetic protein 2/runt-related gene 2 signalling pathway. Journal of Pharmacy and Pharmacology, 66(12), 1763-1773. 42. Siddiqi, M. H., Siddiqi, M. Z., Ahn, S., Kang, S., Kim, Y. J., Sathishkumar, N., ... & Yang, D. C. (2013). Ginseng saponins and the treatment of osteoporosis: mini literature review. Journal of Ginseng Research, 37(3), 261.


	● 등록 특허 1. 생체이용성이 개선된 눈개승마 가공물 및 이의 제조방법, 2020, 등록번호: 1023808120000 2. 유산균을 포함하는 면역 증강용 조성물, 2018, 등록번호: 1020170058832 3. 히알루론산과 진세노사이드의 결합체 및 이의 용도, 2018, 등록번호: 1018719640000 4. 진세노사이드에 대해 당전이 활성을 가지는 단백질 및 이의 용도, 2018,등록번호: 1018568280000 5. 황칠 추출물을 포함하는 금속 나노입자의 제조용 조성물 및 이의 이용, 2017, 등록번호: 1017963700000 6. 두릅나무과 식물의 발효물을 포함하는 항염증 또는 항암용 조성물, 2017, 등록번호: 1017688060000 7. 메조다공성 실리카 나노입자와 진세노사이드의 결합체 및 이의 용도, 2017, 등록번호: 1017480790000

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